The application and function of valine

2022/04/15

Valine deficiency is not uncommon. When valine is insufficient, the function of the central nervous system will be disordered, with ataxia and tremor of the limbs. Through dissecting and sectioning brain tissue, it is found that there is degeneration of red nuclear cells. Patients with advanced liver cirrhosis are prone to form hyperinsulinemia due to liver damage, resulting in a decrease in blood branched-chain amino acids and the ratio of branched-chain amino acids to aromatic amino acids is changed from that of ordinary people. From 3.0 to 3.5 to 1.0 to 1.5, branched-chain amino acid injections such as valine are often used to treat liver failure and the damage to these organs caused by alcohol and drug abuse.

The main application of valine

Valine is one of the three primary branched-chain amino acids. It is a sugar-producing amino acid mainly metabolized by the glucose pathway after oxidative dehydrogenation. It works with leucine (ketogenic amino acid) and isoleucine (sugar-generating and ketogenic amino acid). It interacts with the tricarboxylic acid cycle to realize the transformation of the body's three major nutrients (protein, sugar, and fat). It has the physiological functions of oxidizing energy supply, promoting protein synthesis, inhibiting protein degradation, and promoting gluconeogenesis and plays a vital role in biological applications.

1. Amino acid drugs

Valine is one of the three branched-chain amino acids and is an essential amino acid. It can be combined with other essential amino acids to prepare amino acid infusions and comprehensive amino acid preparations. It can treat liver failure and central nervous system dysfunction.

2. Protect the liver and nervous system

Studies have found that supplementation of branched-chain amino acid preparations such as valine can change the body's metabolic state and reduce the occurrence of complications of liver cirrhosis. It can also inhibit liver cancer, improve the body's immune function, and resist oxidative stress in vitro and in vivo. It is known that branched-chain amino acids can enhance nutritional status by stimulating liver cell synthesis and reducing catabolism after liver injury.

Valine can be used as a treatment drug for hepatic coma. Supplementing valine can prevent hepatic encephalopathy (HE), thereby promoting normal nervous system function. A deficiency 

of valine can cause neurological deficits in the brain, which can cause neurological disorders.

3. As a therapeutic agent to accelerate wound healing

The recovery of surgical patients has a significant effect on external injuries, burns, and burns.

4. Other functions

①Regulate blood sugar

②Treat malnutrition

③Prevent anemia

④Anti-tumor

The rhein-valine adduct synthesized from valine, and rhein has good anti-tumor activity.