The application and function of valine

2022/01/12

Valine deficiency is not uncommon. When valine is insufficient, the function of the central nervous system will be disordered, with ataxia and tremor of the limbs. Through dissecting and sectioning brain tissue, it is found that there is degeneration of red nuclear cells. Patients with advanced liver cirrhosis are prone to form hyperinsulinemia due to liver damage, resulting in a decrease in blood branched-chain amino acids and the ratio of branched-chain amino acids to aromatic amino acids is changed from that of ordinary people. From 3.0 to 3.5 to 1.0 to 1.5, branched-chain amino acid injections such as valine are often used to treat liver failure and the damage to these organs caused by alcohol and drug abuse.

The main application of valine

Valine is one of the three primary branched-chain amino acids. It is a sugar-producing amino acid mainly metabolized by the glucose pathway after oxidative dehydrogenation. It works with leucine (ketogenic amino acid) and isoleucine (sugar-generating and ketogenic amino acid). It interacts with the tricarboxylic acid cycle to realize the transformation of the body's three major nutrients (protein, sugar, and fat). It has the physiological functions of oxidizing energy supply, promoting protein synthesis, inhibiting protein degradation, and promoting gluconeogenesis and plays a vital role in biological applications.

1. Amino acid drugs
Valine is one of the three branched-chain amino acids and is an essential amino acid. It can be combined with other essential amino acids to prepare amino acid infusions and comprehensive amino acid preparations. It can treat liver failure and central nervous system dysfunction.

2. Feed additives
① Adding L-valine to the diet of lactating livestock can increase lactation. When lysine levels are high, valine will become the first restricted amino acid.
②Improve the immune function of the animal body. Valine can promote the conversion of animal bone cells into mature T cells. When animals lack valine, the ability to synthesize specific antibodies will decrease, and the antibody response of the virus will decrease.
③Affect the endocrine level of animals. Studies have shown that adding valine to the diets of lactating sows and lactating rats can increase the concentration of prolactin and growth hormone in the plasma.

3. Nutritional supplements
It can be used as a food additive. Valine (1g/kg) is added to rice cakes. The product has a sesame fragrance. It can also improve the flavor when used in bread.

4. Other functions
For biochemical research, tissue culture medium preparation.

The critical role of tyrosine in the human body

Valine is an important nutrient for the human body. Its main effects on the human body are as follows:

1. Promote the growth and development of the body, repair damaged tissues, and provide the body with energy

Valine is one of the three branched-chain amino acids (BACC) (Note: Leucine, isoleucine, and valine are three essential amino acids with a branched-chain carbon skeleton.) If lacking, it will cause tactile sensitivity. The degree is remarkably improved, and the ataxia of the muscles is imbalanced.

Branched-chain amino acids are closely related to human exercise capacity, can provide energy reserves for long-term endurance exercise, promote muscle protein synthesis, and can regulate the peripheral mechanism that triggers exercise fatigue, delay the appearance of exercise fatigue, and replenish branch chains after exercise Amino acids can also promote recovery from exercise fatigue.

2. Protect the liver and nervous system

Studies have found that supplementation of branched-chain amino acid preparations such as valine can change the body's metabolic state and reduce the occurrence of complications of liver cirrhosis. It can also inhibit liver cancer, improve the body's immune function, and resist oxidative stress in vitro and in vivo. It is known that branched-chain amino acids can enhance nutritional status by stimulating liver cell synthesis and reducing catabolism after liver injury.

Valine can be used as a treatment drug for hepatic coma. Supplementing valine can prevent hepatic encephalopathy (HE), thereby promoting normal nervous system function. A deficiency of valine can cause neurological deficits in the brain, which can cause neurological disorders.

3. As a therapeutic agent to accelerate wound healing

The recovery of surgical patients has a significant effect on external injuries, burns, and burns.

4. Other functions
①Regulate blood sugar
②Treat malnutrition
③Prevent anemia
④Anti-tumor

The rhein-valine adduct synthesized from valine, and rhein has good anti-tumor activity.

To learn more about this product, click here ↓