Synthetic method of hyaluronic acid

2021/12/15

The production process and technology of hyaluronic acid determine the difference in quality. Therefore, the product must be produced from the correct source to have a therapeutic effect. Generally speaking, there are three ways to refine:

1.Animal tissue: The primary raw materials are cockscomb and bull's eye vitreous. The raw materials are defatted and dehydrated with acetone or ethanol, soaked in distilled water, and filtered. It is then treated with an aqueous sodium chloride solution and a chloroform solution, and then trypsin is added for incubation to obtain a mixed solution. Finally, it is treated and purified with an ion exchanger to obtain refined hyaluronic acid.

2.Microbial fermentation: using glucose as a carbon source fermentation broth. Ferment in the culture medium for 48 hours. After the fermentation is completed, filter to remove the mycelium and impurities and then use simple operations such as alcohol precipitation to obtain high-purity products. Hyaluronic acid produced by fermentation has the advantage that the molecular weight can be set according to the product design. The key to the fermentation method is selecting strains, most of which are streptococcus and lactic acid cocci.

3.Chemical synthesis: using natural enzyme polymerization; firstly use polysaccharide polymers to synthesize "hyaluronic acid oxazoline derivatives," then add hydrolytic enzymes to create a complex of derivatives and enzymes, and finally Remove the enzymes in the 90 degree Celsius reaction solution to synthesize hyaluronic acid 

To ensure product quality, the company currently uses microbial fermentation of hyaluronic acid.

Baoding faithful Industry and Trade Co., Ltd. produces professional hyaluronic acid, exported to many countries around the world. It has a comprehensive inspection and testing certificate, stable supply, and fast delivery. It provides you with professional knowledge before a sale and after-sales. Provide professional tracking and guarantee, and we look forward to cooperating with you.

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