The role and indications of pancreatin

2021/12/10

Pancreatin is used in the alternative treatment of impaired pancreatic exocrine function caused by various reasons, such as cystic fibrosis, chronic pancreatitis, post-pancreatectomy, post-gastrectomy, pancreatic duct, or common bile duct obstruction caused by the tumor, and chronic pancreatitis Sexual pain, elderly, gastrointestinal, liver and gallbladder diseases. This product contains various digestive enzymes such as trypsin and amylase, which can digest protein and starch. It also has a digestive effect on fat.

They are used for pancreatic dysfunction, dyspepsia of diabetic patients, etc. This product is most effective when neutral or slightly alkaline, so it is often used in combination with sodium bicarbonate.

Pancreatin can hydrolyze fat, starch, and protein. After oral administration, the capsule dissolves in the stomach and releases hundreds of pancreatin microparticles with enteric coating. Thus, it can avoid inactivation in the stomach, thoroughly mix with food, and enter the duodenum synchronously. The particles disintegrated immediately in the proximal duodenum. More than 80% of the activity was released within 130 min to ensure the digestion and absorption of nutrients.

Taking the same amount of sodium bicarbonate can enhance the curative effect. In addition, cimetidine can inhibit gastric acid secretion and increase the pH in the stomach and duodenum, preventing pancreatic enzyme inactivation and improving the efficacy of oral pancreatic enzymes.

Because all Hz receptor antagonists can reduce gastric acidity, it is speculated that ranitidine, famotidine, and nizatidine also have this interaction with trypsin. Therefore, it may be necessary to reduce the dose of trypsin. The activity of this drug is weakened or even inactivated by splitting in acidic solution, so it should not be taken with acidic drugs. When this drug is combined with acarbose or miglitol, the latter's efficacy is reduced, so it should be avoided to use it at the same time.

Baoding faithful Industry Co., Ltd. produces professional panreatin, exported to Europe, America, Asia, and other countries. It has comprehensive inspection and testing certificates, stable supply, fast delivery, and provides you with professional knowledge on the premises of the sale. , Provide you with professional tracking and guarantee after purchase, and we look forward to cooperating with you.

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